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Current Projects

Definition of cell types currently under study

NSPC: neural stem and progenitor cells, play a key role in repair of the central nervous system. These stem cells turn into the various cell types of the nervous system. E.g. neurons, oligodendrocytes, and astrocytes

Mesemchymal stem cells: These stem cells, isolated from the placenta, turn into osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells). There is evidence that these cells can also behave as NSPC.

iPSC: inducible pluripotent stem cells. These cells are typically mature cells (e.g. skin) that have been genetically reprogrammed to behave like a stem cell by being forced to express genes and factors important for stem cells.

Enteric plexus stem cells: These are cells isolated from the intestines of an individual. There is hope we can derive these to act as NPSC.

Current Projects (both planned and currently ongoing)

  1. Effect of neurotransmitter stimulation of NSPC
  2. Role of HIF and PO2 on NSPC differentiation and proliferation
  3. Mechanism of NSPC migration and differentiation in response to environmental factors
  4. Modulation of NSPC activity in response to immune system responses
  5. Effect of exercise on stem cell populations (e.g. regeneration)
  6. Isolation of factors involved in msemchymal stem cell differentiation.
  7. Genetic determination of atherosclerotic plaque stability and involvement in stroke.
  8. Matrix metalloproteinase activity in cell migration
  9. Modulation of ion channel activity during spinal cord injury
  10. Stem cell transplantation into the injured spinal cord
  11. Drug development