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Publications

In press:

Kopriva D, Karnitski M, Kisheev A, Meena D, Pelle S, Lavoie A, Buttigieg J. (2015). The nature of iron deposits differs between symptomatic and asymptomatic carotid atherosclerotic plaques. PLOS One.

Nurse CA, Salman S, Brown S, Buttigieg J. (2012). Regulation of O2 chemosensitivity in developing adrenal chromaffin cells. Fish Physiology.

Published:

David Kopriva, Andrea Lavoie, Anastasye Kisheev, Josef Buttigieg. (2014) Synchrotron mapping of the carotid artery plaque--A pilot study. J Vasc. Surgery 60:5:1402.

Ludlow K, Buttigieg J. (2013). Not so liberating after all: Multiple Sclerosis disease and treatments. Journal Health Science. Aug. 4: 105-108.

Wu Y, Satkunendrarajah K, Teng Y, Chow DS, Buttigieg J, Fehlings MG (2013). Delayed post-injury administration of riluzole is neuroprotective in preclinical rodent model of spinal cord injury. J Neurotrauma. 30(6):441-52. PMID23517137

Salman S, Buttigieg J, Nurse CA (2013) ontogeny of O2 and Co2/H+ chemosensitivity in adrenal chromaffin cells: role of innervation. J Exp. Biol.

Salman S, Buttigieg J, Zhang M, Nurse CA. (2012). Chronic exposure of neonatal rat adrenomedullary chromaffin cells to opioids in vitro blunts both hypoxia and hypercapnia chemosensitivity. J Physiol. Jan 15;591(Pt 2):515-29. PMID: 23148319

Salewski R, Buttigieg J, Mitchel R, Van der Kooy D, Nagy A, Fehlings M (2012). The generation of definitive neural stem cells frompiggyBac transposon induced pluripotent stem cells can be enhanced by induction of the NOTCH signalling pathway. Stem Cell Dev. 22(3):383-96

Buttigieg J, Pan J, Yeger H, Cutz E (2012). NOX2 (gp91 phox) is a predominant O2 sensor in a human airway chemoreceptor cell line: biochemical, molecular and electrophysiological evidence. Am J lung cell mol phys. 202(7):L598-607

Wu Y, Satkunendrarajah K,  Teng Y, Chow D, Buttigieg J, Fehlings M (2012). Delayed postinjury administration of riluzole is neuroprotective in a preclinical rodent model of cervical spinal cord injury. J Neurotrauma. 30(6):441-52.

Buttigieg J, Nurse CA (2012). Methodologies for studying peripheral O2-chemosensing: past, present and future. Respir physiol Neurobiol; 181(2):194-201.

(co-first author) Ye H,Buttigieg J, Wan Y, Wang J, Figley S, Fehlings MG (2012). Expression and functional role of BK channels in chronically injured spinal cord white matter. Neurobiol Dis; 47(2):225-36

Livermore S, Piskuric N,Buttigieg J, Zhang M, Nurse C (2011). Low glucose sensitivity and polymodal chemosensing in neonatal rat adrenomedullary chromaffin cells. AJP Cell; 301(5):C1104-15.

Buttigieg J, Eftekharpour E, Karimi-Abdolrezaee S, Fehlings MG (2011). Molecular and electrophysiological evidence for the expression of BK channels in Oligodendroglial Precursor Cells. EJN; 34(4):538-547.

Brown ST,Buttigieg J, Nurse C.A (2010). Divergent roles of reactive oxygen species in the responses of perinatal adrenal chromaffin cells to hypoxic challenges. Resp Physiol & Neurobiol. 174(3):252-8.

Nurse CA,Buttigieg J, Brown ST, Holloway A, (2009). Regulation of oxygen sensitivity in adrenal chromaffin cells. Ann N Y Acad Sci;1177:132-9.

Buttigieg J, Brown ST, Nurse CA (2009). Chronic nicotine blunts hypoxic sensitivity in perinatal rat adrenal chromaffin cells via upregulation of KATP channels: Role of H7 nicotinic AChR and hypoxia inducible factor -2H. J Neurosci, 29(22):7137-47.

Buttigieg J, Brown ST, Zhang M, Lowe M, Holloway AC, Nurse CA (2008). Chronic nicotine in utero selectively suppresses hypoxic sensitivity in neonatal rat adrenal chromaffin cells. FASEB J. 22(5):1317-26.

Buttigieg J, Brown ST, Lowe M, Zhang M, Nurse CA (2008). Functional mitochondria are required for O2 but not CO2 sensing in immortalized adrenomedullary chromaffin cells. Am J Cell Physiol. 294(4):C945-56.

(co-first author) Thompson RJ,Buttigieg J, Zhang M, Nurse CA (2007). A rotenone-sensitive site and H2O2 are key components of hypoxia-sensing in neonatal rat adrenomedullary chromaffin cells. Neuroscience 45(1):130-41.

Zhang M,Buttigieg J, Nurse CA (2007).Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body. J Physiol. 578(Pt 3):735-50.6

Buttigieg J, Nurse CA (2004). Detection of hypoxia-evoked ATP release from chemoreceptor cells of the rat carotid body. Biochem Biophys Res Commun; 322(1):82-7.

Jiang S, Khan MI, Wang J,Buttigieg J, Lu Y, Werstiuk ES, Ciccarelli R, Caciagli F, Rathbone MP (2003). Guanosine promotes myelination and functional recovery in chronic spinal injury. Neuroreport; 4(18):2463-7.

Review/Book Chapters

Nurse CA,Buttigieg J, Thompson RJ, Zhang M, Cutz E (2006). Oxygen sensing in neuroepithelial and adrenal chromaffin cells. Novartis Found Symp 114-8, 131-40.

Buttigieg J, Zhang M, Thompson RJ, Nurse CA (2006). Potential role of mitochondria in hypoxia sensing by adrenomedullary chromaffin cells. Adv Exp Med Biol. 580:79-85.