Safely back on campus. Learn More.

Publications

Manzon, R.G., Manzon, L.A. (2017). Lamprey metamorphosis: Thyroid hormone signaling in a basal vertebrate. Molecular and Cellular Endocrinology. (In Press) https://doi.org/10.1016/j.mce.2017.06.015

Whitehouse, L., McDougall, C.S., Stefanovic, D.I., Boreham, D., Somers, C.M., Wilson, J.Y., Manzon, R.G. (2017). Development of the embryonic heat shock response and the impact of repeated thermal stress in early stage lake whitefish (Coregonus clupeaformis) embryos. Journal of Thermal Biology 69:294-301.

Zak, M.A., Regish, A.M., McCormick, S.D., Manzon, R.G. (2017). Exogenous thyroid hormones regulate the activity of citrate synthase and cytochrome c oxidase in warm- but not cold-acclimated lake whitefish (Coregonus clupeaformis). General and Comparative Endocrinology.  247:215-222.

Endsin, M.J., Michalec, O., Manzon, L.A., Lovejoy, D.A., Manzon, R.G. (2017). CRH peptide evolution occurred in three phases: Evidence from characterizing sea lamprey CRH system members. General and Comparative Endocrinology. 240:162-173.

Lee, A.H., Eme, J., Mueller, C.A., Manzon, R.G., Somers, C.M., Boreham, D.R., Wilson, J.Y. (2016). The effects of increased constant incubation temperature and cumulative acute heat shock exposures on morphology and survival of Lake Whitefish (Coregonus clupeaformis) embryos. Journal of Thermal Biology 57:11-20.

Graham, C.F., Eberts, R.L., Morgan, T., Boreham, D.R., Lance, S., Manzon, R.G., Martino, J.A., Rogers, S.M., Wilson, Y.W., Somers, C.M. (2016). Fine-scale ecological and genetic population structure of two Whitefish (Coregoninae) species in the vicinity of industrial thermal emissions.  PLOS ONE; PONE-D-15-46470.

Eberts, R.L., Wissel, B., Manzon, R.G., Wilson, J.Y., Boreham, D., Somers, C.M. (2016) Consistent differential resource use by sympatric Lake (Coregonus clupeaformis) and Round Whitefish (Prosopium cylindraceum) in Lake Huron: a multi-time scale isotopic niche analysis.  Canadian Journal of Fish and Aquatic Sciences. 73: 1072-1080.

Thome, C., Mitz, C, Somers, C.M., Manzon, R.G., Boreham, D.R., Wilson, J.Y.  (2015)  Incubation of Lake Whitefish (Coregonus clupeaformis) embryos in cooling water discharge and the impacts of fluctuating thermal regimes on development.  Canadian Journal of Fish and Aquatic Sciences.  73: 1-9.

Stefanovic, D.I., Manzon, L.A., McDougall, C.S., Boreham, D., Somers, C.M, Wilson, J.Y., Manzon R.G. (2016)  Thermal stress and the heat shock response in embryonic and young of the year juvenile Lake Whitefish. Comparative Biochemistry and Physiology  193:1-10.

Graham, C.F., Glenn, T.C. McArthur, A., Boreham, D.R., Kieran, T., Lance, S., Manzon, R.G., Martino, J.A., Pierson, T., Rogers, S.M., Wilson, J.Y., Somers, C.M. (2015)  Impacts of Degraded DNA on Restriction Enzyme Associated DNA Sequencing (RADSeq). Molecular Ecology Resources  15:1304-1315.

Sreetharan, S., Thome, C., Mitz, C., Eme, J., Mueller, C.A., Hulley, E.N., Manzon, R.G., Somers, C.M., Boreham, D.R., Wilson, J.Y. (2015)  Embryonic development of Lake Whitefish (Coregonus clupeaformis): a staging series, analysis of growth and impacts of fixation.  Journal of Fish Biology  87:539-558.

Mueller, C.A., Eme, J., Manzon, R.G., Somers, C.M., Boreham, D.R., Wilson, J.Y. (2015)  Embryonic critical windows: changes in incubation temperature alter survival, hatchling phenotype and cost of development in Lake Whitefish (Coregonus clupeaformis).  Journal of Comparative Physiology B  185:315-331

Manzon, R.G., Holmes, J.A., Youson, J.H. (2015). Metamorphsois. In: Lampreys: Biology, Conservation and Control. Ed. M.F. Docker. Fish and Fisheries Series. Springer.

Eme, J., Mueller, C.A., Manzon, R.G., Rogers, C.M., Boreham, D.R., Wilson, J.Y. (2014) Critical windows in embryonic development: Shifting incubation temperatures alter heart rate and oxygen consumption of Lake Whitefish (Coregonus clupeaformis) embryos and hatchlings. Comparative Biochemistry and Physiology A. 179:71-81.

Manzon, L.A., Youson, J.H., Holzer, G., Staiano, L., Laudet, V., Manzon, R. G. (2014). Thyroid hormone and retinoid X receptor function and expression during sea lamprey (Petromyzon marinus) metamorphosis. General and Comparative Endocrinology 204:211-222.

Mitz, C., Thome, C., Cybulskia, M., Laframboisea, L., Somers, C., Manzon, R.G., Wilson, J.W., Boreham, D.R. (2014). A self-contained, controlled hatchery system for rearing Lake Whitefish embryos for experimental aquaculture. North American Journal of Aquaculture. 76:179-184.

Manzon, L.A., Youson, J.H., Holzer, G., Staiano, L., Laudet, V., Manzon, R. G. (2014). Thyroid hormone and retinoid X receptor function and expression during sea lamprey (Petromyzon marinus) metamorphosis. General and Comparative Endocrinology 204:211-222.

Mitz, C., Thome, C., Cybulskia, M., Laframboisea, L., Somers, C., Manzon, R.G., Wilson, J.W., Boreham, D.R.  (2014).  A self-contained, controlled hatchery system for rearing Lake Whitefish embryos for experimental aquaculture.  North American Journal of Aquaculture. 76:179-184.

Manzon, R.G., Holmes, J.A., Youson, J.H.  (2014 – In Press).  Metamorphsois.  In:  Lampreys: Biology, Conservation and Control.  Ed.  M.F. Docker.  Fish and Fisheries Series.  Springer.   Invited Chapter

Stilborn, S. S M., Manzon, L.A., Schauenberg, J.D., Manzon, R.G. (2013).  Thyroid hormone deiodinase type 2 expression in sea lamprey (Petromyzon marinus) is regulated during metamorphosis and in response to a thyroid challenge.  General and Comparative Endocrinology.  183:63-68.  (NSERC Discovery, Faculty of Science)

Tetlock, A., Yost, C.K., Stavrinides, J., Manzon, R.G.  (2012).  Changes in the gut microbiome of the sea lamprey during metamorphosis.  Applied and Environmental Microbiology 78:7638-7644.

Youson, J.H. and Manzon, R.G. (2012). Lamprey Metamorphosis. In: S. Doufour; K. Rousseau; and B.G. Kapoor (Eds.). Metamorphosis in Fish. Science Publishers, Enfield, New Hampshire.

Gross, T.N. & Manzon, R.G. (2011). Sea lamprey (Petromyzon marinus) contain four developmentally regulated serum thyroid hormone distributor proteins. General and Comparative Endocrinology. 170. 640-649.

Manzon, R.G. (2011). Thyroidal regulation of life history transitions in fish. In: T. Flatt and A. Heyland (Eds.) Mechanisms of life history transitions. The genetics and physiology of life history traits and trade-offs. Oxford University Press, New York.

Manzon, R.G., Neuls, T.M., Manzon L.A. (2007). Molecular cloning, tissue distribution, and developmental expression of lamprey transthyretins. General and Comparative Endocrinology. 151:55-65.

Boonstra, R., Manzon, R.G., Mihok, S. and Helson, J.E. (2005). Hormetic effects of gamma radiation on the stress axis of natural populations of meadow voles (Microtus pennsylvanicus). Environmental Toxicology and Chemistry 24(2):334-343.

Manzon, R.G. and Denver, R.J. (2004). Regulation of pituitary thyrotropin gene expression duringXenopus metamorphosis: negative feedback is functional throughout metamorphosis. Journal of Endocrinology 182:273-285.

Kao, Y.H., Manzon, R.G., Sheridan, M.A., Leatherland, J.F., Holmes, J.A., and Youson, J.H. (2003). Effect of alloxan and insulin immunoneutralization on circulating thyroid hormone levels in larval landlocked sea lampreys, Petromyzon marinus. Zoological Science 20:635-638.

Manzon, R.G. and Youson, J.H. (2002). KClO4 inhibits thyroidal activity in the larval lamprey endostylein vitro. General and Comparative Endocrinology 128(3): 214-223

Manzon, R.G., Holmes, J.A. and Youson, J.H. (2001). Variable effects of goitrogens in inducing metamorphosis in sea lampreys. Journal of Experimental Zoology. 289(5):290-303

Manzon, R.G. and Youson, J.H. (1999). Temperature and KClO4-induced metamorphosis in the sea lamprey (Petromyzon marinus). Comparative Biochemistry and Physiology 124C:253-257. (Featured article).

Holmes, J.A., Chu H., Khanam S., Manzon R.G. and Youson J.H. (1999). Spontaneous and induced metamorphosis in the American brook lamprey, Lampetra appendix. Canadian Journal of Zoology 77:959-971.

Kao, Y., Manzon R.G., Sheridan M.A. and Youson J.H. (1999). Study of the relationship between thyroid hormones and lipid metabolism during KClO4-induced metamorphosis of landlocked lamprey,Petromyzon marinus. Comparative Biochemistry and Physiology 122C:363-373.

Manzon, R.G., Eales, J.G. and Youson, J.H. (1998). Blocking of KClO4-induced metamorphosis in premetamorphic sea lampreys by exogenous thyroid hormones (TH); effects of KClO4 and TH on serum TH concentrations and intestinal thyroxine outer-ring deiodination. General and Comparative Endocrinology 112:54-62.

Youson, J.H., Manzon, R.G., Peck, B.J. and Holmes, J.A. (1997). Effects of exogenous thyroxine (T4) and triiodothyronine (T3) on spontaneous metamorphosis and serum T4 and T3 levels in immediately premetamorphic sea lampreys, Petromyzon marinus. Journal of Experimental Zoology 279:145-155.

Manzon, R.G. and Youson, J.H. (1997). The effects of exogenous thyroxine (T4) or triiodothyronine (T3), in the presence and absence of potassium perchlorate, on the incidence of metamorphosis and on serum T4 and T3 concentrations in larval sea lampreys (Petromyzon marinus L.). General and Comparative Endocrinology 106:211-220.